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How Wegovy and Mounjaro weight-loss injections work

Overview

Use this article to understand the mechanism of action behind GLP-1 and GIP weight loss injections, how Wegovy® (semaglutide) and Mounjaro® (tirzepatide) control appetite, how weekly self-administration works, and how these treatments combine with lifestyle changes to support weight reduction.


How GLP-1 weight loss injections work in the body

Weight loss injections contain active ingredients that mimic naturally occurring gut hormones released after eating.

  • Appetite control and satiety: These treatments act on brain receptors regulating appetite to reduce food cravings, slow gastric emptying, and create a lasting feeling of fullness.

  • Blood sugar regulation: By aiding natural blood sugar management, the active ingredients assist in maintaining stable blood glucose levels after meals.

  • Weekly self-administration: Treatment is self-administered once per week at home using a pre-filled injection pen fitted with fine, disposable needles designed for comfortable subcutaneous application.

  • Lifestyle combination: Injectable weight loss medications are designed to be used in conjunction with a reduced-calorie diet and regular physical activity to achieve sustained weight loss.


Wegovy® (semaglutide)

Wegovy® is an injectable weight management medication containing the active ingredient semaglutide.

  • Active ingredient: Semaglutide functions as a GLP-1 receptor agonist, mimicking the natural GLP-1 hormone in the gut.

  • General eligibility: Wegovy® is indicated for adults with a Body Mass Index (BMI) of 30 kg/m² or higher (obesity). It may also be prescribed for individuals with a BMI between 27 kg/m² and 30 kg/m² (overweight) who present with weight-related co-morbidities such as high blood pressure, diabetes, cardiovascular disease, or elevated cholesterol.


Mounjaro® (tirzepatide)

Mounjaro® is an injectable weight loss medication containing the active ingredient tirzepatide, administered via a pre-filled pen.

  • Active ingredient: Tirzepatide acts as a dual GIP and GLP-1 receptor agonist, mimicking two intestinal hormones to control appetite and promote satiety.

  • Lifestyle integration: Mounjaro® is prescribed alongside a calorie-reduced diet and increased physical activity to support effective, healthy weight management.


Additional Assistance

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