Overview
Use this article to understand the protocol-led steps to follow if you experience side effects or intolerance after escalating your weight-loss medication dose, including dose adjustment options and clinical authorisation requirements.
Protocol for managing dose intolerance
If you experience persistent side effects—such as continuous nausea, vomiting, or diarrhea—after escalating to a higher dose, follow these clinical management steps:
Do not escalate your dose: Never increase your dosage while active gastrointestinal side effects or intolerance symptoms persist. Dose progression should only occur when your body has fully adapted to the current dose.
Consult the patient information leaflet: Review the package insert included with your medication for initial advice on side effect management.
Contact the MedExpress care team: If side effects remain troublesome or persistent, contact the MedExpress clinical service team before administering your next scheduled dose.
Clinical options for dose adjustment
Any change to your prescribed treatment schedule or dose strength must be clinically reviewed and authorised by an EU-registered doctor. Based on a medical evaluation, your prescribing clinician may recommend one of the following adjustments:
Remaining on your current dose: Maintaining your existing dose level for one or more additional cycles to give your body extra time to tolerate the medication.
Delaying dose titration: Temporarily postponing a planned dose increase until all adverse symptoms have completely resolved.
Temporary dose reduction: Decreasing your prescribed dosage strength back to the previously well-tolerated dose level to manage severe side effects safely.
Urgent symptoms requiring medical evaluation
While mild gastrointestinal effects are common during dose adjustments, severe or persistent symptoms require immediate clinical attention:
Urgent medical care: If you experience severe abdominal pain, uncontrollable vomiting, signs of severe dehydration, or any concerning symptoms, seek immediate medical assessment from a local primary care doctor, hospital, or emergency services.
Additional Assistance
If you still need help after reviewing the information above, additional assistance is available.